WebJul 9, 2012 · Acute decompensated heart failure (ADHF) represents new or worsening symptoms of heart failure that necessitate hospitalization. 1, 2 As a leading cause of hospitalization in patients older than 65 years, ADHF is one of the most costly cardiovascular disorders. 3, 4 Acute decompensated heart failure is associated with … WebMar 29, 2024 · Hanrahan JP, de Boer IH, Bakris GL, Wilson PJ, Wakefield JD, Seferovic JP, Chickering JG, Chien YT, Carlson K, Cressman MD, Currie MG, Milne GT, Profy AT. Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial. Clin J Am Soc Nephrol. 2024 Dec …
The Role of Vericiguat in the Expanding Realm of Heart …
WebFeb 26, 2007 · These beneficial properties make direct soluble guanylate cyclase stimulation with BAY 58-2667 a promising new therapeutic strategy for cardiovascular … WebTwo clinical trials (SOCRATES-REDUCED and VICTORIA) have evaluated the safety and efficacy of vericiguat in patients with HFrEF. Table 2 Clinical Trials Evaluating Soluble … greens mailing house
Soluble guanylate cyclase stimulators in patients with heart failure ...
WebHitherto, the central cGMP-forming enzyme, soluble guanylate cyclase (sGC), has been targeted pharmacologically exclusively for smooth muscle modulation in cardiology and pulmonology. Here, we examine the disease associations of sGC in a non-hypothesis based manner in order to identify possibly previously unrecognized clinical indications. WebBackground: Several randomized controlled trials (RCTs) have been investigated the benefits of soluble guanylate cyclase (sGC) stimulators in the treatment of heart failure, but a comprehensive evaluation is lacking. We performed a meta-analysis to evaluate the efficacy and safety of oral sGC stimulators ( vericiguat and riociguat) in patients ... WebBackground—Endothelial dysfunction of the peripheral vasculature is a well-known phenomenon in congestive heart failure that contributes to the elevated peripheral ... the expression of protein and mRNA of the endothelial nitric oxide synthase (eNOS), inducible NOS (iNOS), and soluble guanylate cyclase (sGC), and superoxide anion (O2 ... fmw 12v 35w bulb led