Ion channel trafficking
Web23 feb. 2024 · Ca V channels are multiprotein complexes and their functional expression in the plasma membrane involves finely tuned mechanisms, including forward trafficking from the endoplasmic reticulum (ER) to the plasma membrane, endocytosis and recycling. Web1 jan. 2024 · Dysregulation of ion channel surface density due to inherited or de novo mutations underlies many serious diseases, and molecules that can correct trafficking deficits are potential therapeutics and useful research tools. We have developed targeted ubiquitination and deubiquitination approaches that enable selective posttranslational …
Ion channel trafficking
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Web25 jan. 2024 · Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associates with aberrant ion channel trafficking. Cellular processes underlying trafficking are … WebAt the department of Medical Physiology, we focus on trafficking of the repolarizing ion channels that underlie IKr and IK1. We are beginning to learn that ion channels traffic …
WebAt the department of Medical Physiology, we focus on trafficking of the repolarizing ion channels that underlie IKr and IK1. We are beginning to learn that ion channels traffic in channel-specific pathways using particular interacting proteins that target them to their destination membranes. Web16 apr. 2013 · At present, it is not known which chemical substructures in pentamidine are important for selective disruption of hERG ion channel trafficking. Our results indicate that the aromatic residues, in particular, are essential, as modifications of these groups (PA-3 and 4) have a large effect on hERG ion channel trafficking.
WebRESEARCH INTEREST: Our research focuses on how subunits that are part of the cardiac voltage-gated sodium channel localize at the cell surface. NaV1.5 is the pore-forming α subunit, and its trafficking and activity are regulated by associated β subunits, as well as by other components of the channel; their proper localization is imperative for adequate ion … WebChapter 23 TRP Channel Trafficking Rosa Planells-Cases and Antonio Ferrer-Montiel. Author Information Cellular function, in particular neuronal activity, is the result of an orchestrated interplay between membrane …
Web25 jan. 2024 · SARS coronaviruses encode several mysterious proteins such as Orf3a and, in contrast to what has been claimed, Orf3a is not an ion channel but rather disrupts cellular trafficking by binding to the protein sorting complex known as HOPS.
WebDrug-induced ion channel trafficking disturbance can cause cardiac arrhythmias. The subcellular level at which drugs interfere in trafficking pathways is largely unknown. K … nottingham apc doacWeb1 jan. 2016 · Ion channel trafficking in both healthy physiology and disease pathophysiology is discussed with special emphasis on connexin 43 (Cx43) gap … nottingham apc otitis externaWeb1 jan. 2024 · Ion channels are integral membrane proteins that sense changes in the extracellular and intracellular environments and respond by facilitating rapid ion flux … how to shoot best wedding photographyWeb25 mei 2024 · * Special areas of expertise include ion channel biology, blood brain barrier, and protein trafficking * Excellent communication and presentation skills evidenced by productive collaborations and ... how to shoot better in da hoodA fascinating question relates to the nature of the molecular mechanisms which regulate ion channel targeting into distinct subdomains of the sarcolemma and their tethering in large molecular complexes. Cardiac myocytes are structurally and functionally highly polarized cells. While the transmission … Meer weergeven The function of the heart is governed by the electrical and mechanical activity of myocytes. The functional expression of several different types of ion channels in the myocyte … Meer weergeven The IKr current is encoded by the human ether-a-go-go–related gene (HERG, also known as KCNH2) in the heart (Sanguinetti … Meer weergeven Cardiomyocytes are exposed to mechanical forces when the heart contracts. These forces consist of stretch, shear and … Meer weergeven Cardiac excitability can be regulated by cellular lipid content. Free cholesterol is a major lipid class shown to regulate membrane fluidity, curvature, and stiffness (Lundbaek et al., 1996). The function of several … Meer weergeven how to shoot better in 2k22Web2 apr. 2013 · A growing number of drugs interfere with normal trafficking of ion channels to and from the plasma membrane, thereby altering the number of channels on the cell … nottingham apc h pyloriWebKv1.5, which underlies the atrial specific I(Kur) current, is a major focus of research efforts seeking new therapeutic strategies and targets. Recent work has shown a novel effect of … nottingham apc hrt