WebJun 19, 2007 · Purified rat Acot7 from brain cytoplasmic extracts ... Arachidonoyl-CoA is the precursor of archidonate in the plasma membrane, which is released by phospholipase A2. Acot7 overexpression might deplete the membrane of this eicosanoid precursor. Conversely, Acot7 itself might generate free arachidonic acid from arachidonoyl-CoA, or … WebApr 12, 1994 · Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein …
Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis …
WebMar 27, 2024 · The effect of sPLA2 on human lymphatic endothelial cells was investigated by culturing human lymphatic endothelial cells. Secretory phospholipases A2 (sPLA2) showed high expression levels in lymphoedema tissues, however, cytoplasmic phospholipases A2 (cPLA2), showed low expression in lymphoedema, as demonstrated … WebOct 1, 2024 · Among them, cytoplasmic phospholipase A2 (cPLA2), the key enzyme of the pro-inflammatory mediator, was the most significantly down-regulated protein. And enriched KEGG pathway shown that PPAR-γ pathway was most involved. Taxifolin significantly reduced p-cPLA2 and increased PPAR-γ protein level in keratinocytes and … mals pals dorchester
Cytoplasmic Phospholipase A2 Levels Correlate with Apoptosis …
WebWe found an overexpression of cytoplasmic PLA2 in superficial stromal cells. These cells corresponded to fibroblasts and myofibroblasts. There was an association between the number of cytoplasmic PLA2 and COX-2-expressing cells (P=0.006). Cytoplasmic PLA2-positive stromal cells usually also expressed COX-2. WebGeneral Function. Phospholipase a2 activity. Specific Function. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Pfam Domain Function. WebCytosolic phospholipase A 2 (cPLA2) is a calcium-dependent enzyme that cleaves fatty acids, such as arachidonic acid, from phospholipids by hydrolyzing the SN-2 acyl bond … malspam definition