WebSep 10, 2024 · Autophagic/lysosomal dysfunction is a critical pathogenesis of neuronal injury after ischemic stroke. Trehalose has been validated to restore the impaired autophagy flux by boosting transcription factor EB (TFEB) nuclear translocation, but orally administrated trehalose can be greatly digested by intestinal trehalase before entering … Web14 hours ago · CTSB-mediated pyroptosis is an important contributor to the pro-inflammatory macrophage polarization in the spleen and the systemic inflammatory response induced by BaP and DBP co- exposure. ... A. Williams, T. Li, H. Chavan, P. Krishnamurthy, X. C. He, L. Li, A. Ballabio, H. M. Ni, and W. X. Ding. 2024. Impaired …
Cells Free Full-Text Tfeb-Mediated Transcriptional Regulation of ...
WebMar 21, 2024 · CTSB (Cathepsin B) is a Protein Coding gene. Diseases associated with CTSB include Keratolytic Winter Erythema and Annular Erythema . Among its related pathways are Collagen chain trimerization and Innate Immune System . Gene Ontology (GO) annotations related to this gene include peptidase activity and cysteine-type … WebScale bar: 10 μm. (D) Quantitative RT-PCR analyses of ciliobrevin A- and dynasore-treated cells showed increased transcription of TFEB target genes (LC3, SQSTM1, MCOLN1, CTSB, CTSF, and TFEB) after inhibition of endocytosis with dynasore or inhibition of retrograde trafficking with ciliobrevin A. Bar graphs represent fold change in mRNA levels ... solana consensus algorithm
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WebJan 13, 2024 · Although the downregulation of Tfeb in the heart significantly decreased the number of autophagic vacuoles and inhibited autosis during I/R, the activation of Tfeb activity via 3,4-dimethoxychalcone, an activator of Tfeb, aggravated myocardial injury during I/R. ... Gabarap and Vps11, and lysosomal function, including Ctsb, Ctsd, Hexb, Cln3 … WebJan 27, 2024 · S211 in TFEB is responsible for phosphorylation-dependent interaction with YWHA/14-3-3 proteins. It has been reported that phosphorylation of TFEB at S142 and/or S211 is essential for controlling TFEB subcellular localization and affecting its transcriptional activity possibly by interacting with YWHA/14-3-3 proteins (Figure 1(a–b)) [].To further … WebAcronym. Definition. CSTB. Centre Scientifique et Technique du Bâtiment (French: Scientific Center and Technical Building) CSTB. Computer Science and Telecommunications … sluhn allentown pediatrics