Cisplatin transporter

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August undefined, 2024

WebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a …

IJMS Free Full-Text Multifaceted Mechanisms of Cisplatin …

WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … WebSep 6, 2012 · Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity. For this reason, other platinum … the palm seattle

Role of transporters in the distribution of platinum-based …

WebSep 18, 2024 · NCBI Bookshelf WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, ... membrane-bound mechanosensitive sodium … WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ... the palm seawoods

KRAS and EGFR Mutations Differentially Alter ABC Drug Transporter ...

Inhibition of OCT2, MATE1 and MATE2-K as a possible …

WebApr 14, 2024 · Flavonoids are enriched in various vegetables, fruits, and herbal products, and some were reported to produce transporter-mediated DDIs. This study aimed to screen potential inhibitors of OCT2 from 96 flavonoids, assess the nephroprotective effects on cisplatin-induced kidney injury, and clarify the structure-activity relationships of ... WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … the palms destinWebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin … the palms downtown phoenix

"WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. " - Cisplatin transporter

Cisplatin transporter

WebMar 9, 2024 · SLC11A2, also known as DMT1 (divalent metal transporter 1), is a metal transporter that has been shown to control the pool of cytoplasmic iron 32, therefore affecting the drug activation step... Web(mate1) mediate cellular transport of cisplatin. Transporter mediated uptake has been shown to be an important process mediating cellular accumulation of cisplatin. Cisplatin is one of the most widely utilized antitumor drugs in the world [6]. Cisplatin was the first platinum-based drug that revolutionized the treatment of neoplastic diseases.

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WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebIn addition, cisplatin is the standard treatment of patients with non-small cell lung cancer (NSCLC) when druggable mutations are not present in the tumour 34. Hence, Pt drugs have not been...

WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. WebCisplatin triggers rapid degradation of Copper Transporter 1, reducing influx of cisplatin and increasing resistance to it. Explore the transporter in PDB ID 6m97 . Glutathione transferase (GST) P1-1 is a cisplatin-binding protein that can inactivate cisplatin.

WebHydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. ... of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κ B pathway and regulating transporter mediated drug efflux. Journal of Ethnopharmacology, 2024 ... WebOct 5, 2014 · The uptake of cisplatin is mediated by the copper transporter Ctr1 in yeast and mammals (Ishida, Lee et al., 2002). It has been further confirmed in human cells that cisplatin triggers rapid degradation of the copper membrane transporter CTR1, with diminished influx of cisplatin, resulting in resistance to the drug ( Lin, Okuda et al., 2002 ...

WebOct 7, 2002 · Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. …

WebThe direction of MATE1 transport is defined by the proton concentration gradient: when assayed in vitro at pH 7.4 or higher, MATE1 behaves as an uptake transporter, whereas … the palm seafood sampler appetizerWebJan 17, 2024 · System x c − is one among many amino acid transporters expressed in the plasma membrane of mammalian cells 1.This transporter is composed of xCT (SLC7A11), which is the substrate-specific ... shutters inside houseWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … the palm seafood towerWebwww.ncbi.nlm.nih.gov shutters inside mountWebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 … shutters inside window frameWebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS, in the Journal: (JOURNAL) what: In this study, total CTR1 levels (comprising plasma_membrane-associated and intracellular … the palms dominican republicWebEffects of siRNA-GLUT-1 and LY294002 on apoptosis and cell cycle in Hep-2 cells after treatment with cisplatinBefore the cisplatin treatment, the apoptotic rates of cells in the siRNA-GLUT-1 and LY294002 groups were increased markedly at 24 hours and 48 hours compared with the Hep-2 cell and siRNA-NC groups (P<0.05; Figure 2).The early … the palms destin fl airbnb