Chrna2 thermogenesis
WebJul 6, 2024 · We found that CHRNA2 signaling is activated after acute high fat diet feeding and this effect is manifested through both UCP1- and creatine-mediated mechanisms. Furthermore, our data suggested that CHRNA2 signaling may activate glycolytic beige fat, a subpopulation of beige adipocytes mediated by GABPα emerging … WebThe CHRNA2 gene is responsible for producing a subunit known as α2. Little is known about the specific function of nAChR proteins made with this subunit. In the brain, nAChR proteins are widely distributed and play an important role in chemical signaling between nerve cells (neurons).
Chrna2 thermogenesis
Did you know?
WebCHRNA2 was discovered to promote thermogenesis in uncoupling protein 1 (Ucp1)-positive beige adipocytes through a cAMP-and protein kinase A-dependent pathway. Further research on its role in... WebChemical stimulation with β 3-adrenergic agonists (CL316,243) or cold exposure is known to promote the development of BeAT. The morphological, biochemical, and physiological characteristics of WAT …
WebCHRNA2 signaling mediates thermogenesis through both uncoupling protein 1 (UCP1)- and creatine-dependent pathways. The contribution of thermogenic adipocytes to maintain systemic metabolic homeostasis has been increasingly appreciated in recent years. WebDec 1, 2024 · CHRNA2: a new paradigm in beige thermoregulation and metabolism DOI: 10.1016/j.tcb.2024.11.009 Authors: Yingxu Ma Shanshan Liu Hee-Jin Jun Pennington Biomedical Research Center Jun Wu Abstract...
WebApr 12, 2024 · It has been found that neuronal acetylcholine receptor subunit alpha 2 (CHRNA2) senses ChAMs-produced acetylcholine in beige adipocytes and activates thermogenesis through UCP1- and creatine futile cycling-mediated pathways ( 92, 94 ). CHRNA2 has been identified as a unique marker for activated beige adipocytes. WebJun 12, 2024 · Thermogenic fat cells, also called beige fat or beige adipocytes, have gained attention in recent years for their potential to curb obesity and other metabolic disorders, due to their ability to burn energy stored as fat. But scientists have yet to translate this potential into effective therapies.
WebAdipose tissue (AT) is classified based on its location, physiological and functional characteristics. Although there is a clear demarcation of anatomical and molecular features specific to white (WAT) and brown adipose tissue (BAT), the factors that uniquely differentiate beige AT (BeAT) remain to be fully elaborated. The ubiquitous presence of …
WebJul 14, 2024 · Thermogenesis is a facultative mechanism that manifests itself in response to various external stresses such as temperature, exercise, and diet, and evolutionary fine-tuning has resulted in an array of adaptive pathways that regulate the thermogenic response ( … child vampire wigWebJun 12, 2024 · Thermogenic gene expression and mitochondrial metabolism were impaired in CHRNA2-deficient inguinal fat during chronic cold exposure, and less protection against high fat diet (HFD) feeding was observed in fat-specific Chrna2 knockout (KO) mice, whereas no obvious defects were observed at basal level. child vampire manifestation mod sims 4WebInguinal Thermogenic Defects by Adipose-Specific Chrna2 Deletion This newly generated mouse model with adipose-specific dele- tion of Chrna2 now allows us to directly test the hypothesis that the thermogenic defects observed in the IWAT of whole-body Chrna2 KO mice are mediated through an adipocyte-autono- mous mechanism (Jun et al., 2024). gpo fruit trading tier listWebNicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an … child vampire teethWebJun 6, 2024 · The authors found that the expression of CHRNA2 is upregulated in activated beige fat cells from subcutaneous adipose depots. They demonstrated that that a subgroup of acetylcholine-producing... gpo fruit trading tier list 4.5WebJul 6, 2024 · Thermogenic gene expression and mitochondrial metabolism were impaired in CHRNA2-deficient inguinal fat during chronic cold exposure, and less protection against high fat diet (HFD) feeding was observed in fat-specific Chrna2 knockout (KO) mice, whereas no obvious defects were observed at basal level. gpo fruit worth tier listWebMay 22, 2024 · To better understand what makes beige fat unique, Prof Wu and her colleagues analysed activated beige fat and uncovered a molecule directly linked to thermogenesis in these cells: CHRNA2 (for cholinergic receptor nicotinic alpha 2), a type of receptor that is best known for regulating nicotine dependence in brain cells. child vanity